Artículos de revistas
Synthesis, characterization and cytotoxic activities of the [RuCl(2)(NO)(dppp)(L)]PF(6) complexes
Fecha
2010Registro en:
JOURNAL OF INORGANIC BIOCHEMISTRY, v.104, n.5, p.489-495, 2010
0162-0134
10.1016/j.jinorgbio.2009.12.015
Autor
GOLFETO, Camilla C.
POELHSITZ, Gustavo Von
SELISTRE-DE-ARAUJO, Heloisa S.
ARAUJO, Marcio P. de
ELLENA, Javier
CASTELLANO, Eduardo Ernesto
LOPES, Luiz G. L.
MOREIRA, Icaro S.
BATISTA, Alzir A.
Institución
Resumen
The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 mu M against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized = 200 mu M). (C) 2009 Elsevier Inc. All rights reserved.