Artículos de revistas
Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of insulin-like activity
Fecha
2009Registro en:
INORGANICA CHIMICA ACTA, v.362, n.2, p.414-420, 2009
0020-1693
10.1016/j.ica.2008.04.029
Autor
MENDES, Isolda C.
BOTION, Leida M.
FERREIRA, Adaliene V. M.
CASTELLANO, Eduardo E.
BERALDO, Heloisa
Institución
Resumen
Reaction of VOCl(2) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH) Cl(2)] (1), [VO(H2Am4Me) Cl(2)] center dot 1/2HCl (2), [VO(H2Am4Et) Cl(2)] center dot HCl (3) and [VO(2Am4Ph) Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of [VO(2)(2Am4DH)] (5), [VO(2)(2Am4Me)] (6), [VO(2)(2Am4Et)] (7) and [VO(2)(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. (C) 2008 Elsevier B.V. All rights reserved.