Artículos de revistas
Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate
Fecha
2009Registro en:
LETTERS IN DRUG DESIGN & DISCOVERY, v.6, n.3, p.210-214, 2009
1570-1808
Autor
GUIDO, Rafael Victorio Carvalho
BALLIANO, Tatiane L.
ANDRICOPULO, Adriano Defini
OLIVA, Glaucius
Institución
Resumen
Kinetic and crystallographic studies on the formation of the complex between iodoacetate and the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi were conducted in order to investigate the mechanistic and structural basis underlying enzyme inactivation. The crystallographic complex reveal important structural features useful for the design of novel inhibitors.