Artículos de revistas
A hands-on approach for fitting long-term survival models under the GAMLSS framework
Date
2010Registration in:
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v.97, n.2, p.168-177, 2010
0169-2607
10.1016/j.cmpb.2009.08.002
Author
CASTRO, Mario de
CANCHO, Vicente G.
RODRIGUES, Josemar
Institutions
Abstract
In many data sets from clinical studies there are patients insusceptible to the occurrence of the event of interest. Survival models which ignore this fact are generally inadequate. The main goal of this paper is to describe an application of the generalized additive models for location, scale, and shape (GAMLSS) framework to the fitting of long-term survival models. in this work the number of competing causes of the event of interest follows the negative binomial distribution. In this way, some well known models found in the literature are characterized as particular cases of our proposal. The model is conveniently parameterized in terms of the cured fraction, which is then linked to covariates. We explore the use of the gamlss package in R as a powerful tool for inference in long-term survival models. The procedure is illustrated with a numerical example. (C) 2009 Elsevier Ireland Ltd. All rights reserved.