Artículos de revistas
In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis
Fecha
2008Registro en:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.52, n.12, p.4522-4525, 2008
0066-4804
10.1128/AAC.00448-08
Autor
TAVARES, Patricia M.
THEVISSEN, Karin
CAMMUE, Bruno P. A.
FRANCOIS, Isabelle E. J. A.
BARRETO-BERGTER, Eliana
TABORDA, Carlos P.
MARQUES, Alexandre F.
RODRIGUES, Marcio L.
NIMRICHTER, Leonardo
Institución
Resumen
We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans, inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis.