Artículos de revistas
Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
Fecha
2009Registro en:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.53, n.5, p.2149-2152, 2009
0066-4804
10.1128/AAC.00693-08
Autor
LOPES, Stefanie C. P.
BLANCO, Yara C.
JUSTO, Giselle Z.
NOGUEIRA, Paulo A.
RODRIGUES, Francisco L. S.
GOELNITZ, Uta
WUNDERLICH, Gerhard
FACCHINI, Gustavo
BROCCHI, Marcelo
DURAN, Nelson
COSTA, Fabio T. M.
Institución
Resumen
Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.