Artículos de revistas
Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?
Fecha
2011Registro en:
AMYOTROPHIC LATERAL SCLEROSIS, v.12, n.2, p.144-147, 2011
1748-2968
10.3109/17482968.2010.542002
Autor
MENDONCA, Deise M. F.
MARTINS, Sheila C. S.
HIGASHI, Rafael
MUSCARA, Marcelo N.
MOURA NETO, Vivaldo
CHIMELLI, Leila
MARTINEZ, Ana Maria B.
Institución
Resumen
The objectives of this study were to investigate the presence of the three neurofilament subunits, ubiquitin, proteasome and 3-nitrotyrosine, in CSF samples of ALS patients. CSF samples were obtained by lumbar puncture from 10 ALS patients and six controls. All samples were analysed by Western blotting. Results revealed that neurofilament heavy subunit was identified in 70% of ALS cases and we conclude that this subunit may be a promising biomarker for clinical diagnosis of ALS.