Artículos de revistas
Odor cues from tumor-bearing mice induces neuroimmune changes
Fecha
2010Registro en:
BEHAVIOURAL BRAIN RESEARCH, v.214, n.2, p.357-367, 2010
0166-4328
10.1016/j.bbr.2010.06.003
Autor
ALVES, Glaucie Jussilane
VISMARI, Luciana
LAZZARINI, Ricardo
MERUSSE, Jose Luis Bernardino
PALERMO-NETO, Joao
Institución
Resumen
Cohabitation for 14 days with an Ehrlich tumor-bearing mice was shown, among others, to increase locomotor activity, and hypothalamic noradrenaline levels and turnover, to decrease the innate immune responses and animal resistance to tumor growth. The present experiment was designed to access the relevance of tactile, olfactory, and visual communication to the neuroimmune changes induced by cohabitation with a tumor-bearing partner. Mice that were not allowed to perceive odor cues from their sick partners presented no alterations in neutrophil activity, a fact not observed after visual deprivation and physical isolation. Mice use scents for intraspecies communication in many social contexts. Tumors produce volatile organic compounds released into the atmosphere through breath, sweat, and urine. The present results strongly suggest that volatile compounds released by Ehrlich tumor-injected mice are perceived by their conspecifics, inducing the neuroimmune changes reported for cohabitation with a sick companion. (C) 2010 Published by Elsevier B.V.