Artículos de revistas
Involvement of the central nervous system in the chronic form of Chagas` disease
JOURNAL OF THE NEUROLOGICAL SCIENCES, v.269, n.1/Fev, p.152-157, 2008
WACKERMANN, Paula Viana
FERNANDES, Regina Maria Franca
ELIAS JR., Jorge
SANTOS, Antonio Carlos dos
MARQUES JR., Wilson
BARREIRA, Arnilton Antunes
Background and purpose: Apart from the central nervous system parasitic invasion in chagasic immunodeficient patients and strokes due to heart lesions provoked by the disease, the typical neurological syndromes of the chronic phase of Chagas` disease (CD) have not yet been characterized, although involvement of the peripheral nervous system has been well documented. This study aims at investigating whether specific signs of central nervous system impairment might be associated with the disease. Methods: Twenty-seven patients suffering from the chronic form of Chagas` disease (CCD) and an equal number of controls matched for sex, age, educational and socio-cultural background, and coming from the same geographical regions, were studied using neurological examinations, magnetic resonance images, and electroencephalographic frequency analysis. Results: Nineteen patients were at the stage A of the cardiac form of the disease (without documented structural lesions or heart failure). Dizziness, brisk reflexes, and ankle and knee areflexia were significantly more prevalent in the patients than in the controls. The significant findings in quantitative electroencephalogram were an increase in the theta relative power and a decrease in the theta dominant frequency at temporal-occipital derivations. Subcortical, white matter demyelination was associated with diffuse theta bursts and theta-delta slowing in two patients. Conclusions: Our findings suggest a discrete and unspecific functional cortical disorder and possible white matter lesions in CD. The focal nervous system abnormalities in CD documented here did not seem to cause significant functional damage or severely alter the patient`s quality of life. (C) 2008 Elsevier B.V. All rights reserved.
Showing items related by title, author, creator and subject.
Santos, Daniel Rui Diniz; Andrade, Gabriela Chagas Freitas de; Santos, Daniel Rui Diniz; Andrade, Gabriela Chagas Freitas de (2005)O conhecimento dos fatores de risco para doenças cardiovasculares é importante, não apenas para direcionar corretamente estratégias preventivas, como para identificar indivíduos sob risco cardiovascular, mesmo que não ...
Campêlo, Maria das Graças Loureiro das Chagas; Campêlo, Maria das Graças Loureiro das Chagas (Programa de Pós-Graduação em Medicina e Saúde, 2013)Indivíduos com doença de Parkinson idiopática (DPI) podem apresentar neuropatia periférica, o que pode agravar o desempenho motor. A causa da neuropatia periférica nesses pacientes é controversa. Objetivos- Identificar a ...
Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans Bandeira, Maurício de Sousa; Santos, Cleiton S.; Azevedo, Everton C. de; Soares, Luciane Marieta; Macedo, Júlio O.; Marchi, Samyra; Silva, Caroline Luane R. da; Chagas Júnior, Adenizar Delgado das; McBride, Alan J. A.; Reis, Mitermayer Galvão dos; McBride, Flávia W. C.; Athanazio, Daniel Abensur; Bandeira, Maurício de Sousa; Santos, Cleiton S.; Azevedo, Everton C. de; Soares, Luciane Marieta; Macedo, Júlio O.; Marchi, Samyra; Silva, Caroline Luane R. da; Chagas Júnior, Adenizar Delgado das; McBride, Alan J. A.; Reis, Mitermayer Galvão dos; McBride, Flávia W. C.; Athanazio, Daniel Abensur (2011)The aims of this study were to investigate the frequency of pulmonary hemorrhage (PH) in mice unable to produce functional B and T lymphocytes and to explore the effect of an inducible nitric oxide synthase gene (Inos) ...