Artículos de revistas
Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease
Fecha
2009Registro en:
JOURNAL OF NEUROIMMUNOLOGY, v.214, n.1/Fev, p.128-131, 2009
0165-5728
10.1016/j.jneuroim.2009.07.004
Autor
FERNANDES, Karla S. S.
BRUM, Doralina Guimaraes
SANDRIM, Valeria Cristina
GUERREIRO, Carlos Tostes
BARREIRA, Amilton Antunes
TANUS-SANTOS, Jose Eduardo
Institución
Resumen
Multiple sclerosis (MS) is an autoimmune disease causing severe neurological disability. This study was carried out in order to determine whether the MMP-9 C(-1562)T and (CA)(13-25) polymorphisms are associated with MS. A total of 165 patients (92 whites/73 mulattos) and 191 controls (96 whites/95 mulattos) were enrolled in the study. While no difference in C(-1562)T polymorphism was observed between MS and healthy subjects, (CA)(n) genotypes and alleles were associated with MS. Moreover, the haplotypes are not associated with MS but seem to be relevant to the clinical status of MS. Thus the (CA)(n) polymorphism may contribute to MS susceptibility, but C(-1562)T and (CA)(n) haplotypes may modulate disease severity. (c) 2009 Elsevier B.V. All rights reserved.