Artículos de revistas
Cardiovascular effects of acetylcholine microinjection into the ventrolateral and dorsal periaqueductal gray of rats
Fecha
2011Registro en:
BRAIN RESEARCH, v.1371, p.74-81, 2011
0006-8993
10.1016/j.brainres.2010.11.051
Autor
DEOLINDO, Milena Vieira
PELOSI, Gislaine Garcia
BUSNARDO, Cristiane
RESSTEL, Leonardo Barbosa Moraes
CORREA, Fernando Morgan Aguiar
Institución
Resumen
In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL) into the vlPAG caused dose-related depressor responses. These hypotensive responses were blocked by local pretreatment with increasing doses of the nonselective muscarinic antagonist atropine (1, 3 or 9 nmol/50 nL). The microinjection of Ach into the dPAG caused no significant cardiovascular responses in anesthetized rats. In conclusion, the present findings suggest that a cholinergic system present in the vlPAG, but not in the dPAG, is involved with cardiovascular system control. Moreover, these cardiovascular responses evoked by Ach are mediated by muscarinic receptors. (C) 2010 Elsevier B.V. All rights reserved.