Artículos de revistas
T allele of-344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension
Fecha
2009Registro en:
HYPERTENSION RESEARCH, v.32, n.2, p.159-162, 2009
0916-9636
10.1038/hr.2008.36
Autor
LACCHINI, Riccardo
SABHA, Maricene
COELI, Fernanda B.
FAVERO, Fabricio F.
YUGAR-TOLEDO, Juan
IZIDORO-TOLEDO, Tatiane C.
SANDRIM, Valria C.
TANUS-SANTOS, Jose E.
MELLO, Maricilda P. de
MORENO JR., Heitor
Institución
Resumen
Resistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different antihypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P < 0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups.