Artículos de revistas
Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia
Fecha
2009Registro en:
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, v.31, n.4, p.453-456, 2009
1751-5521
10.1111/j.1751-553X.2008.01036.x
Autor
OLIVEIRA, F. M. de
TONE, L. G.
SIMOES, B. P.
REGO, E. M.
MARINATO, A. F.
JACOMO, R. H.
FALCAO, R. P.
Institución
Resumen
P>We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derivated from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, with proliferation of CD4(-) CD8(+). The co-existence of two translocations involving both sex chromosomes in a case of T-PLL is rare. Chromosomal instability associated with the disease progression may have allowed the emergence of cell clones with translocations involving the sex chromosomes and the ring chromosome observed.