Artículos de revistas
Abnormal corpus callosum myelination in pediatric bipolar patients
Fecha
2008Registro en:
JOURNAL OF AFFECTIVE DISORDERS, v.108, n.3, p.297-301, 2008
0165-0327
10.1016/j.jad.2007.10.006
Autor
CAETANO, Sheila C.
SILVEIRA, Camila Magalhaes
KAUR, Simerjit
NICOLETTI, Mark
HATCH, John P.
BRAMBILLA, Paolo
SASSI, Roberto
AXELSON, David
KESHAVAN, Matcheri S.
RYAN, Neal D.
BIRMAHER, Boris
SOARES, Jair C.
Institución
Resumen
Background: Decreased signal intensity in the corpus callosum, reported in adult bipolar disorder patients, has been regarded as an indicator of abnormalities in myelination. Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients. Methods: Children and adolescents with DSM-lV bipolar disorder (n=16, mean age +/- S.D. = 15.5 +/- 3.4 y) and matched healthy comparison subjects (n=21, mean age +/- S.D.=16.9 3.8 y) underwent a 1.5 T MRI brain scan. Corpus callosuin signal intensity was measured using an Apple Power Mac G4 running NIH Image 1.62 software. Results: Bipolar children and adolescents had significantly lower corpus callosum signal intensity for all callosal sub-regions (genu, anterior body, posterior body, isthmus and splenium) compared to healthy subjects (ANCOVA, all p < 0.05, age and gender as covariates). Limitations: Relatively small sample size. Conclusions: Abnormalities in corpus callosum, probably due to altered myelination during neurodevelopment, may play a role in the pathophysiology of bipolar disorder among children and adolescents. (c) 2007 Elsevier B.V All rights reserved.