Artículos de revistas
Low DNA HTLV-2 proviral load among women in Sao Paulo city
Fecha
2008Registro en:
VIRUS RESEARCH, v.135, n.1, p.22-25, 2008
0168-1702
10.1016/j.virusres.2008.01.015
Autor
MONTANHEIRO, Patricia
OLAH, Ingrid
FUKUMORI, Ligia M. I.
SMID, Jerusa
OLIVEIRA, Augusto Cesar Penalva de
KANZAKI, Luis I. B.
FONSECA, Luiz Augusto M.
DUARTE, Alberto J. S.
CASSEB, Jorge
Institución
Resumen
Background: HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HlV-1 co-infection. Methods: We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10(4) PBMCs. Results: Six of 53 HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 CopieS/10(4) PBMCs, p < 0.05). Conclusions: We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus. (c) 2008 Elsevier B. V. All rights reserved.