dc.creator | MEDEIROS, Fabricio Witzel de | |
dc.creator | MOHAN, Rajiv R. | |
dc.creator | SUTO, Chilkako | |
dc.creator | SINHA, Sunilima | |
dc.creator | BONILHA, Vera L. | |
dc.creator | CHAURASIA, Shyam S. | |
dc.creator | WILSON, Steven E. | |
dc.date.accessioned | 2012-10-19T18:26:20Z | |
dc.date.accessioned | 2018-07-04T15:13:11Z | |
dc.date.available | 2012-10-19T18:26:20Z | |
dc.date.available | 2018-07-04T15:13:11Z | |
dc.date.created | 2012-10-19T18:26:20Z | |
dc.date.issued | 2008 | |
dc.identifier | JOURNAL OF REFRACTIVE SURGERY, v.24, n.9, p.923-927, 2008 | |
dc.identifier | 1081-597X | |
dc.identifier | http://producao.usp.br/handle/BDPI/23444 | |
dc.identifier | http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000260842500012&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1620174 | |
dc.description.abstract | PURPOSE: To compare mechanical and ethanol epithelial removal with respect to myofibroblast development and haze formation after photorefractive keratectomy (PRK). METHODS: Seventeen rabbits underwent mechanical or ethanol debridement, and the opposite eye of each rabbit served as an unwounded control. In both groups, the epithelium was removed with a spatula and discarded. A -9.00-diopter PRK was performed in each eye. The level of haze in each cornea at 4 weeks was graded at the slit-lamp microscope according to the Fantes scale. Myofibroblast generation was detected with immunocytochemistry for alpha-smooth muscle actin (alpha-SMA) and cells were quantitatively analyzed. RESULTS: No difference was noted between the two groups in alpha-SMA + myofibroblasts 4 weeks after surgery (43.6 +/- 2.0/400X field and 45.7 +/- 4.8/400X field in ethanol and mechanical groups, respectively) (P=.10). A slight difference was noted but did not reach statistical significance with regard to stromal haze between ethanol and mechanical groups (2.0 +/- 0.5 and 2.3 +/- 0.4, respectively, P=.063). The ethanol and mechanical groups were statistically different when compared to controls regarding stromal haze and alpha-SMA+ cells (P <.0001 for all comparisons). CONCLUSIONS:No difference was noted in clinical haze or myofibroblast generation between corneas that had PRK with mechanical,or ethanol epithelial debridement. [J Refract Surg., 2008;24:923-927.] | |
dc.language | eng | |
dc.publisher | SLACK INC | |
dc.relation | Journal of Refractive Surgery | |
dc.rights | Copyright SLACK INC | |
dc.rights | restrictedAccess | |
dc.title | Haze Development After Photorefractive Keratectomy: Mechanical vs Ethanol Epithelial Removal in Rabbits | |
dc.type | Artículos de revistas | |