Artículos de revistas
Recurrent neuromyelitis optica in Brazilian patients: clinical, immunological, and neuroimaging characteristics
Fecha
2010Registro en:
MULTIPLE SCLEROSIS, v.16, n.1, p.81-86, 2010
1352-4585
10.1177/1352458509353651
Autor
ADONI, T.
LINO, A. M. M.
GAMA, P. D. da
APOSTOLOS-PEREIRA, S. L.
MARCHIORI, P. E.
KOK, F.
CALLEGARO, D.
Institución
Resumen
Neuromyelitis optica has not been thoroughly studied in Brazilian patients following the discovery of NMO-IgG and its specific antigen aquaporin-4. In this study we aimed to describe the clinical NMO-IgG immunological status and neuroimaging characteristics of recurrent neuromyelitis optica in a series Brazilian patients. We undertook a retrospective study of 28 patients with recurrent neuromyelitis optica, according to 1999 Wingerchuk`s diagnostic criteria. Data on NMO-IgG status, clinical features, and MRI findings were analyzed. Three men and 25 women were evaluated. Median age at onset of disease was 26 years (range 7-55); median time of follow-up was 7 years (range 2-14). The mean time elapsed between the first and the second attack was 17 months (median 8.5; range 2-88). NMO-IgG was detected in 18 patients (64.3%). Four patients died due to respiratory failure. Most patients presented with cervical (36%) and cervical-thoracic myelitis (46.4%). Holocord lesion was the most common pattern of involvement (50%) on the axial plane. We did not find a statistical association between myelitis extension and NMO-IgG result. Our series of Brazilian patients showed a younger age of onset than previously reported. In our series, in contrast to previous reports, there was no correlation between the extension of myelitis and NMO-IgG positivity.