Artículos de revistas
Immunohistochemical evaluation of macrophage activity and its relationship with apoptotic cell death in the polar forms of leprosy
Fecha
2010Registro en:
MICROBIAL PATHOGENESIS, v.49, n.4, p.135-140, 2010
0882-4010
10.1016/j.micpath.2010.05.003
Autor
QUARESMA, Juarez Antonio Simoes
LIMA, Luiz Wagner de Oliveira
FUZII, Hellen Thais
LIBONATI, Rosana Maria Feio
PAGLIARI, Carla
DUARTE, Maria Irma Seixas
Institución
Resumen
The objective of the present study was to investigate the correlation between macrophage activity and apoptosis in the polar forms of leprosy because the immunopathological phenomena involved in these forms are still poorly understood For this purpose, 29 skin biopsy samples obtained from patients with the polar forms of leprosy were analyzed. Macrophage activity and apoptosis were evaluated by immunohistochemistry using lysozyme, CD68, iNOS and caspase 3 as markers The nonparametric Mann-Whitney test and Spearman`s linear correlation test were used for statistical analysis The results suggest that the apoptosis rate is under the direct influence of macrophage activity in lesions of patients with the tuberculoid form In contrast, in lepromatous lesions other factors seem to induce programmed cell death, possibly TGF-beta. Further studies are necessary to identify additional factors involved in the immunopathogenesis of leprosy. (C) 2010 Elsevier Ltd. All rights reserved