Artículos de revistas
Cost-effectiveness analysis of a hypothetical hepatitis C vaccine compared to antiviral therapy
Fecha
2009Registro en:
EPIDEMIOLOGY AND INFECTION, v.137, n.2, p.241-249, 2009
0950-2688
10.1017/S0950268808000873
Autor
MASSAD, E.
COUTINHO, F. A. B.
CHAIB, E.
BURATTINI, M. N.
Institución
Resumen
We propose a mathematical model to simulate the dynamics of hepatitis C virus (HCV) infection in the state of Sao Paulo, Brazil. We assumed that a hypothetical vaccine, which cost was taken to be the initial cost of the vaccine against hepatitis B exists and it is introduced in the model. We computed its cost-effectiveness compared with the anti-HCV therapy. The calculated basic reproduction number was 1.20. The model predicts that without intervention a steady state exists with an HCV prevalence of 3%, in agreement with the Current epidemiological data. Starting from this steady state three interventions were simulated: indiscriminate vaccination, selective vaccination and anti-HCV therapy. Selective vaccination proved to be the strategy with the best cost-effectiveness ratio, followed by indiscriminate vaccination and anti-HCV therapy.