Artículos de revistas
Parvovirus among Patients with Cytopenia of Unknown Origin in Brazil: a Case-Control Study
Fecha
2011Registro en:
JOURNAL OF CLINICAL MICROBIOLOGY, v.49, n.4, p.1578-1580, 2011
0095-1137
10.1128/JCM.00077-11
Autor
GARCIA, Sheila de Oliveira
KLEINE NETO, Walter
COSTA, Antonio Charlys da
SANABANI, Sabri Saeed
MENDRONE JR., Alfredo
PEREIRA, Juliana
SABINO, Ester Cerdeira
Institución
Resumen
The molecular prevalence of human parvovirus B19V (B19V) in bone marrow (BM) samples from 120 cases with cytopenias of unknown etiology was compared with that in samples from 45 BM donors (control group 1) and 120 oncohematological patients (control group 2) to determine the role that B19V genotypes may play in unexplained cytopenias. Of the 285 participants, the BM samples of 39 (13.7%) contained B19V DNA (21 with genotype 1, 5 with genotype 2, and 13 with genotype 3). The prevalences of B19V were similar between case and control subjects (15.0% versus 12.7%, respectively). Genotypes 2 and 3 were associated with older age and were detected in similar proportions between case and control group 2 subjects. The results of this study do not support a role for B19V genotype variants in the etiology of unexplained cytopenias.