Artículos de revistas
The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer
Fecha
2009Registro en:
EUROPEAN JOURNAL OF CANCER, v.45, n.13, p.2418-2424, 2009
0959-8049
10.1016/j.ejca.2009.06.018
Autor
PINHEIRO, Celine
LONGATTO-FILHO, Adhemar
SIMOES, Kleber
JACOB, Carlos Eduardo
BRESCIANI, Claudio Jose Caldas
ZILBERSTEIN, Bruno
CECCONELLO, Ivan
ALVES, Venancio Avancini Ferreira
SCHMITT, Fernando
BALTAZAR, Fatima
Institución
Resumen
The aim of the present work was to assess the role of monocarboxylate transporters (MCTs), namely MCT1 and MCT4 as well as MCT/CD147 co-expression in gastric tissues and evaluate their clinico-pathological significance in gastric carcinoma. For that, we analysed the immunohistochemical expression of MCT1, MCT4 and CD147, in a large series of gastric samples, including non-neoplastic, tumour and metastatic tissues. A significant decrease in MCT4 plasma membrane expression was observed from non-neoplastic to gastric primary malignant tissues and to lymph-node metastasis and both MCT1 and MCT4 correlated with CD147. Importantly, both MCT4 and CD147 were more frequently expressed in Lauren`s intestinal-type tumours and MCT1/CD147 co-expression was associated with advanced gastric carcinoma, Lauren`s intestinal type, TNM staging and lymph-node metastasis. Our results showed that the prognostic value of CD147 was associated with MCTI co-expression in gastric cancer cells, supporting the view that CD147 plasma membrane activity is dependent on MCT co-expression. (C) 2009 Elsevier Ltd. All rights reserved.