Artículos de revistas
Cationic technetium and rhenium complexes with pendant carbohydrates
Fecha
2010Registro en:
APPLIED RADIATION AND ISOTOPES, v.68, n.6, p.1087-1093, 2010
0969-8043
10.1016/j.apradiso.2010.01.033
Autor
FERREIRA, Cara L.
MARQUES, Fabio L. N.
OKAMOTO, Miriam R. Y.
OTAKE, Andreia H.
SUGAI, Yuko
MIKATA, Yuji
STORR, Tim
BOWEN, Meryn
YANO, Shigenobu
ADAM, Michael J.
CHAMMAS, Roger
ORVIG, Chris
Institución
Resumen
Three carbohydrate conjugated dipicolylamine chelators, 2-bis(2-pyridinylmethyl)amino)ethyl 1-deoxy-1-thio-beta-D-glucopyranoside (L(1)), 2-bis(2-pyridinylmethyl)amino)ethyl-beta-D-glucopyranoside (L(2)), and 2-bis(2-pyridinylmethyl)amino)carboxamide-N-(2-amino-2-deoxy-D-glucopyranose) (L(3)) were complexed to the [M(Co)(3)](+) core (M=Tc, Re) and the properties of the resulting complexes were investigated. Synthesis and characterization of the chelator 2-bis(2-pyridinylmethyl)amino)ethyl 1-deoxy-1-thio-beta-D-glucopyranoside (L(1)) and the corresponding Re complex are reported. All chelators were radiolabeled in high yield with [(99)mTc(CO)(3)(H(2)O)(3)](+) ( > 98%) and [(186)Re(CO)(3)(H(2)O)(3)](+) ( > 80%). The chelators and Re-complexes were determined to not be substrates for the glucose metabolism enzyme hexokinase. However, the biodistribution of each of the (99m)Tc complexes demonstrated fast clearance from most background tissue, including >75% clearance of the activity in the kidneys and the liver within 2 h post-injection. (C) 2010 Elsevier Ltd. All rights reserved.