dc.creatorLOGULLO, Angela Flavia
dc.creatorSTIEPCICH, Monica Maria Agata
dc.creatorOSORIO, Cintia Aparecida Bueno de Toledo
dc.creatorNONOGAKI, Sueli
dc.creatorPASINI, Fatima Solange
dc.creatorROCHA, Rafael Malagoli
dc.creatorSOARES, Fernando Augusto
dc.creatorBRENTANI, Maria M.
dc.date.accessioned2012-10-19T17:19:43Z
dc.date.accessioned2018-07-04T15:06:22Z
dc.date.available2012-10-19T17:19:43Z
dc.date.available2018-07-04T15:06:22Z
dc.date.created2012-10-19T17:19:43Z
dc.date.issued2011
dc.identifierHISTOPATHOLOGY, v.58, n.4, p.617-625, 2011
dc.identifier0309-0167
dc.identifierhttp://producao.usp.br/handle/BDPI/21878
dc.identifier10.1111/j.1365-2559.2011.03785.x
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2559.2011.03785.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1618651
dc.description.abstractAims: Fos-related antigen 1 (Fra-1) is a member of the activator protein 1 (AP-1) transcription factor family. Our objective was to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis. Methods and results: Fra-1 expression was investigated by immunohistochemistry in two tissue microarrays containing, respectively, 85 ductal carcinoma in situ (DCIS) and 771 invasive ductal carcinoma (IDC) samples. Staining was observed in the nucleus and cytoplasm of the carcinomas, but only nuclear staining was considered to be positive. Fibroblasts associated with IDC were also Fra-1-positive. The frequency of Fra-1 positivity in IDC (22.8%) was lower than that in DCIS (42.2%). No association was found between Fra-1 and clinico-pathological variables in DCIS. In IDC, Fra-1 expression correlated with aggressive phenotype markers, including: high grade, oestrogen receptor negativity and human epidermal growth factor receptor 2 (HER-2) positivity (P = 0.001, 0.015 and 0.004, respectively), and marginally with the presence of metastasis (P = 0.07). Fra-1 was more frequently positive in basal-like (34%) and in HER-2-positive (38.5%) subtypes than in luminal subtypes. Fra-1 presence did not correlate with survival. Conclusions: A high frequency of Fra-1 in DCIS tumours may be associated with early events in breast carcinogenesis. Although Fra-1 expression correlated with features of a more aggressive phenotype in IDC, no relationship with overall survival was found.
dc.languageeng
dc.publisherWILEY-BLACKWELL
dc.relationHistopathology
dc.rightsCopyright WILEY-BLACKWELL
dc.rightsrestrictedAccess
dc.subjectductal breast carcinoma
dc.subjectFra-1
dc.subjectprognosis
dc.subjectprogression
dc.titleRole of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma
dc.typeArtículos de revistas


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