Artículos de revistas
Loss of heterozygosity of the APC gene in oral squamous cell carcinoma
Fecha
2008Registro en:
PATHOLOGY RESEARCH AND PRACTICE, v.204, n.11, p.793-797, 2008
0344-0338
10.1016/j.prp.2008.05.003
Autor
RIVERO, Elena R. C.
HORTA, Martinho C. R.
GUERRAE, Eliete N. Silva
FERRAZ, Alberto R.
NUNES, Fabio D.
Institución
Resumen
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved.