Artículos de revistas
Biomimetic Oxidation of Piperine and Piplartine Catalyzed by Iron(III) and Manganese(III) Porphyrins
Fecha
2010Registro en:
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, n.5, p.912-916, 2010
0918-6158
Autor
SCHAAB, Estela Hanauer
CROTTI, Antonio Eduardo Miller
IAMAMOTO, Yassuko
KATO, Massuo Jorge
LOTUFO, Leticia Veras Costa
LOPES, Norberto Peporine
Institución
Resumen
Synthetic metalloporphyrins, in the presence of monooxygen donors, are known to mimetize various reactions of cytochrome P450 enzymes systems in the oxidation of drugs and natural products. The oxidation of piperine and piplartine by iodosylbenzene using iron(III) and manganese(III) porphyrins yielded mono- and dihydroxylated products, respectively. Piplartine showed to be a more reactive substrate towards the catalysts tested. The structures of the oxidation products were proposed based on electrospray ionization tandem mass spectrometry.