Artículos de revistas
The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea
Fecha
2009Registro en:
PHYTOMEDICINE, v.16, n.11, p.1059-1063, 2009
0944-7113
10.1016/j.phymed.2009.03.019
Autor
SILVA, D. B. da
TULLI, E. C. O.
MILITAO, G. C. G.
COSTA-LOTUFO, L. V.
PESSOA, C.
MORAES, M. O. de
ALBUQUERQUE, S.
SIQUEIRA, J. M. de
Institución
Resumen
The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity IC(50) 0.01 mu M). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 mu M) than other alkaloids tested. (C) 2009 Elsevier GmbH. All rights reserved.