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Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi
Fecha
2010Registro en:
IMMUNOBIOLOGY, v.215, n.5, p.427-434, 2010
0171-2985
10.1016/j.imbio.2009.05.005
Autor
BRAZAO, Vania
SANTELLO, Fabricia Helena
CAETANO, Leony Cristina
FILIPIN, Marina Del Vecchio
TOLDO, Miriam Paula Alonso
PRADO JR., Jose Clovis do
Institución
Resumen
Chagas` disease is considered the sixth most important neglected tropical disease worldwide. Considerable knowledge has been accumulated concerning the role of zinc on cellular immunity. The steroid hormone dehydroepiandrosterone (DHEA) is also known to modulate the immune system. The aims of this paper were to investigate a possible synchronization of their effects on cytokines and NO production and the resistance to Trypanosoma cruzi during the acute phase of infection. It was found that zinc, DHEA or zinc and DHEA supplementation enhanced the immune response, as evidenced by a significant reduction in parasitemia levels. Zinc and DHEA supplementation exerted additive effects on the immune response by elevation of macrophage counts, and by increasing concentrations of IFN-gamma and NO. (C) 2009 Elsevier GmbH. All rights reserved.