Artículos de revistas
Antimicrobial Activity of Terpenoids from Copaifera langsdorffii Desf. Against Cariogenic Bacteria
Fecha
2011Registro en:
PHYTOTHERAPY RESEARCH, v.25, n.2, p.215-220, 2011
0951-418X
10.1002/ptr.3244
Autor
SOUZA, Ariana B.
MARTINS, Carlos H. G.
SOUZA, Maria G. M.
FURTADO, Niege A. J. C.
HELENO, Vladimir C. G.
SOUSA, Joao P. B. de
ROCHA, Erilda M. P.
BASTOS, Jairo K.
CUNHA, Wilson R.
VENEZIANI, Rodrigo C. S.
AMBROSIO, Sergio R.
Institución
Resumen
In the present work, the anticariogenic activities of nine labdane type-diterpenes and four sesquiterpenes were investigated. Among these metabolites, (-)-copalic acid (CA) was the most active compound displaying MIC values very promising (ranging from 2.0 to 6.0 mu g/mL) against the main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis and Lactobacillus casei. Time kill assays performed with CA against the primary causative agent (S. mutans) revealed that, in the first 12 h, this compound only inhibits the growth of the inoculum (bacteriostatic effect). However, its bactericidal effect is clearly noted thereafter (between 12 and 24 h). Also, CA did not show a synergistic effect when combined with the anticariogenic gold standard (chlorhexidine, CHD) in the checkerboard assays against S. mutans. In conclusion, the results points out CA as an important metabolite in the search for new effective anticariogenic agents. Copyright (C) 2010 John Wiley & Sons, Ltd.