Artículos de revistas
Trypanocidal Activity of Pimarane Diterpenes from Viguiera arenaria (Asteraceae)
Fecha
2008Registro en:
PHYTOTHERAPY RESEARCH, v.22, n.10, p.1413-1415, 2008
0951-418X
10.1002/ptr.2512
Autor
AMBROSIO, Sergio R.
ARAKAWA, Nilton S.
ESPERANDIM, Viviane R.
ALBUQUERQUE, Sergio de
COSTA, Fernando B. Da
Institución
Resumen
Five structurally related pimarane diterpenes isolated from the roots of Viguiera arenaria and a further compound obtained by chemical derivatization were evaluated in vitro against the trypomastigote forms of Trypanosoma cruzi. The natural compound ent-15-pimarene-8 beta,19-diol and the derivative ent-8(14),15-pimaradiene-3 beta-acetoxy showed the highest trypanocidal activity, displaying IC50 values of 116.5 +/- 1.21 and 149.3 +/- 1.07 mu M, respectively, while the positive control, violet gentian, showed an IC50 of 76 mu M. Based on the results, it can be concluded that minor structural differences among the tested diterpenes influence significantly the trypanocidal activity, thus bringing new perspectives to the establishment of structure-activity relationships among this type of metabolites to the treatment of Chagas` disease. Copyright (C) 2008 John Wiley & Sons, Ltd.