Artículos de revistas
Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration
Fecha
2008Registro en:
NUTRITION RESEARCH, v.28, n.11, p.791-797, 2008
0271-5317
10.1016/j.nutres.2008.08.006
Autor
VINOLO, Marco Aurelio Ramirez
CRISMA, Amanda Rabello
NAKAJIMA, Karina
ROGERO, Marcelo Macedo
FOCK, Ricardo Ambrosio
BORELLI, Primavera
Institución
Resumen
The aim of this Study was to determine if protein-energy malnutrition Could affect the hematologic response to granulocyte colony-stimulating factor (G-CSF). Swiss mice were fled a low-protein diet containing 4% protein, whereas control mice were fed a 20% protein-containing diet. After the malnourished group lost 20% of their original body weight, the mice were subdivided in 2 treatment groups, and hematopoietic parameters were studied. Mice were injected with either 8 mu g/kg per day of G-CSF or saline twice daily for 4 days. Malnourished mice developed anemia with reticulopenia and leukopenia with depletion of granulocytes and lymphocytes. Both malnourished and control mice treated with G-CSF showed a significant increase in neutrophils; however, in the control group, this increase was more pronounced compared to the malnourished group (4.5-fold and 3.4-fold, respectively). Granulocyte colony-stimulating factor administration increased bone marrow blastic (P < .001) and granulocytic (P < .01) compartments in the controls bill had no significant effect oil these hematopoietic compartments in the Malnourished animals (P = .08 and P = .62, respectively). We report that malnourished mice display an impaired response to G-CSF, which contributes to the decreased production of leukocytes in protein-energy malnutrition. (C) 2008 Elsevier Inc. All rights reserved.