Artículos de revistas
Does mobilization for autologous stem cell transplantation damage stromal layer formation?
Fecha
2009Registro en:
HEMATOLOGY, v.14, n.2, p.76-83, 2009
1024-5332
10.1179/102453309X385232
Autor
SCHIMIEGUEL, Dulce Marta
DOMINATO, Juliana Augusta Albieri
ZATTAR, Karin Cecyn
SILVA, Maria Regina Regis
SOUZA, Marlon Knabben de
NADER, Helena Bonciani
BORELLI, Primavera
OLIVEIRA, Jose Salvador Rodrigues de
Institución
Resumen
Autologous hematopoietic stem cell transplantation (HSCT) has proved efficient to treat hematological malignancies. However, some patients fail to mobilize HSCs. It is known that the microenvironment may undergo damage after allogeneic HSCT. However little is known about how chemotherapy and growth factors contribute to this damage. We studied the stromal layer formation(SLF) and velocity before and after HSC mobilization, through long-term bone marrow culture from 22 patients and 10 healthy donors. Patients` SLF was similar at pre- (12/22)and post-mobilization (9/20), however for controls this occurred more at pre- mobilization (9/10; p=0.03). SLF velocity was higher at pre than post-mobilization in both groups. Leukemias and multiple myeloma showed faster growth of SLF than lymphomas at post-mobilization, the latter being similar to controls. These findings could be explained by less uncommitted HSC in controls than patients at post-mobilization. Control HSCs may migrate more in response to mobilization, resulting in a reduced population by those cells.