Artículos de revistas
X-ray diffraction data of tibolone Delta(4) isomer (isotibolone)
Fecha
2009Registro en:
POWDER DIFFRACTION, v.24, n.4, p.337-342, 2009
0885-7156
10.1154/1.3257612
Autor
ANTONIO, Selma Gutierrez
FERREIRA, Fabio Furlan
ARAUJO, Gabriel Lima Barros
MATOS, Jivaldo do Rosario
PAIVA-SANTOS, Carlos de Oliveira
Institución
Resumen
Tibolone is used for hormone reposition of postmenopause women and isotibolone is considered the major degradation product of tibolone. Isotibolone can also be present in tibolone API raw materials due to some inadequate synthesis. Its presence is then necessary to be identified and quantified in the quality control of both API and drug products. In this work we present the indexing of an isotibolone X-ray diffraction pattern measured with synchrotron light (lambda=1.2407 angstrom) in the transmission mode. The characterization of the isotibolone sample by IR spectroscopy, elemental analysis, and thermal analysis are also presented. The isotibolone crystallographic data are a=6.8066 angstrom, b=20.7350 angstrom, c=6.4489 angstrom, beta=76.428 degrees, V=884.75 angstrom(3), and space group P2(1), rho(o)= 1.187 g cm(-3), Z=2. (C) 2009 International Centre for Diffraction Data. [DOI: 10.1154/1.3257612]