Artículos de revistas
The relative effects of severe burn injury and pre- and post-natal protein deprivation on mandibular condyle morphology
Fecha
2010Registro en:
HISTOLOGY AND HISTOPATHOLOGY, v.25, n.1, p.45-54, 2010
0213-3911
Autor
OLIVEIRA, Bruna Cecilia Caixeta de
OLIVEIRA, Flavia de
MARTINI, Dorival Terra
ROSANA, Cleide
PRISCO, Duarte
RIGUETTI, Marta Maria da Silva
LIBERTI, Edson Aparecido
BOLDRINI, Silvia de Campos
Institución
Resumen
The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the growth and development of the CP under conditions of pre- and postnatal protein deficiency, combined with or without the stress of severe burn injury (BI). We found that protein deficiency severely undermined the growth of the CP, by altering the thickness of its constituent layers. BI is also capable of affecting CP growth, although the effect is less severe than protein deficiency. Interestingly, the summed effect of protein deficiency and BI on the CP is less severe than protein deficiency alone. A possible explanation is that the increased carbohydrates in a hypoproteic diet stimulate the production of endogenous insulin and protein synthesis, which partially compensates for the loss of lean body mass caused by BI.