Artículos de revistas
Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation
JOURNAL OF RADIATION RESEARCH, v.50, n.1, p.61-71, 2009
FACHIN, Ana Lucia
MELLO, Stephano Spano
JUNTA, Cristina Moraes
DONADI, Eduardo Antonio
PASSOS, Geraldo Aleixo da Silva
SAKAMOTO-HOJO, Elza Tiemi
Ionizing radiation OR) imposes risks to human health and the environment. IR at low doses and low (lose rates has the potency to initiate carcinogenesis. Genotoxic environmental agents such as IR trigger a cascade of signal transduction pathways for cellular protection. In this study, using cDNA microarray technique, we monitored the gene expression profiles in lymphocytes derived from radiation-ex posed individuals (radiation workers). Physical dosimetry records on these patients indicated that the absorbed dose ranged from 0.696 to 39.088 mSv. Gene expression analysis revealed statistically significant transcriptional changes in a total of 78 genes (21 up-regulated and 57 clown-regulated) involved in several biological processes such as ubiquitin cycle (UHRF2 and PIAS1), DNA repair (LIG3, XPA, ERCC5, RAD52, DCLRE1C), cell cycle regulation/proliferation (RHOA, CABLES2, TGFB2, IL16), and stress response (GSTP1, PPP2R5A, DUSP22). Some of the genes that showed altered expression profiles in this study call be used as biomarkers for monitoring the chronic low level exposure in humans. Additionally, alterations in gene expression patterns observed in chronically exposed radiation workers reinforces the need for defining the effective radiation dose that causes immediate genetic damage as well as the long-term effects on genomic instability, including cancer.
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Extremely high UV-C radiation resistant microorganisms from desert environments with different manganese concentrations Paulino-Lima I.G.; Fujishima K.; Navarrete J.U.; Galante D.; Rodrigues F.; Azua-Bustos A.; Rothschild L.J. (Elsevier B.V., 2016)
Two thermal methods to measure the energy fluence of a brief exposure of diagnostic x rays Carvalho, A. A.; Mascarenhas, S.; DePaula, M. H.; Cameron, J. R.
Two thermal methods to measure the energy fluence of a brief exposure of diagnostic x rays Universidade Estadual Paulista (Unesp) (1992-07-03)This paper describes two simple thermal methods for measuring the energy fluence in J/cm 2 from a diagnostic x-ray exposure. Both detectors absorb essentially 100% of the radiation and give a signal that is directly ...