Artículos de revistas
Augmented muscle vasodilatory responses in obese children with Glu27 beta(2)-adrenoceptor polymorphism
Fecha
2008Registro en:
PEDIATRIC EXERCISE SCIENCE, v.20, n.2, p.157-168, 2008
0899-8493
Autor
Silva, Alexandre G. da
Ribeiro, Mauricio M.
Trombetta, Ivani C.
Nicolau, Christiane
Frazzatto, Eliana
Guazzelli, Isabel
Matos, Luciana N. J.
Halpern, Alfredo
Negrão, Carlos E.
Villares, Sandra M. F.
Institución
Resumen
This study examined forearm vasodilatation during mental challenge and exercise in 72 obese children (OC; age = 10 +/- 0.1 years) homozygous with polymorphism in the allele 27 of the beta(2)-adrenoceptors: Gln27 (n = 61) and Glu27 (n = 11). Forearm blood flow was recorded during 3 min of each using the Stroop color-word test (MS) and handgrip isometric exercise. Baseline hemodynamic and vascular measurements were similar. During the MS, peak forearm vascular conductance was significantly greater in group Glu27 (Delta = 0.35 +/- 0.4 vs. 0.12 +/- 0.1 units, respectively, p = .042). Similar results were found during exercise (Delta = 0.64 +/- 0.1 vs. 0.13 +/- 0.1 units, respectively, p = .035). Glu27 OC increased muscle vasodilatory responsiveness upon the MS and exercise.