Artículos de revistas
Preparation of PVP hydrogel nanoparticles using lecithin vesicles
Fecha
2010Registro en:
Química Nova, v.33, n.10, p.2083-2087, 2010
0100-4042
10.1590/S0100-40422010001000015
Autor
BUENO, Vânia Blasques
CATALANI, Luiz Henrique
DAGHASTANLI, Katia Regina Perez
CUCCOVIA, Iolanda Midea
CHAIMOVICH, Hernan
Institución
Resumen
Hydrogels micro, sub-micro and nanoparticles are of great interest for drug encapsulation and delivery or as embolotherapic agents. In this work it is described the preparation of nano and sub-microparticles of pre-formed, high molecular weight and monomer free poly(N-vinyl-2-pyrrolidone) encapsulated inside the core of lecithin vesicles. The hydrogel particles are formed with a very narrow diameter distribution, of about 800 nm, and a moderate swelling ratio, of approximately 10.