Artículos de revistas
SYNTHESIS AND DPPH RADICAL SCAVENGING ACTIVITY OF PRENYLATED PHENOL DERIVATIVES
The synthesis of twenty six prenylated phenols derivatives is reported. These compounds were obtained under mild conditions via Electrophilic Aromatic Substitution (EAS) coupling reactions between phenol derivatives containing electron-donor subtituents and 3-methyl-2-buten-1-ol using BF3 center dot OEt2. Dialkylations were also produced with this method. The formation of a chroman ring by intramolecular cyclization between a sp(2) carbon from the prenyl group with the hydroxyl substituent in the ortho position occurred with some phenols. All the synthesized compounds were evaluated as antioxidants according to a DPPH radical scavenging activity assay. IC50 values of five synthesized compounds indicated they were as good antioxidants as Trolox (TM).