The study examined the occupational activities of female graduates in science and technology related fields with a view to assessing factors influencing their performance and make recommendations to enhance women work experiences in S&T occupations. The data for the study was collected through questionnaire and interview schedule from a sample of 2110 respondents comprising of employed female Science and Technology (S&T) graduates and heads of departments in tertiary institutions and S&T firms in Nigeria. The study reveal that most female S&T graduates (FSTGs) employed in tertiary institutions and research institutions were engaged in S&T based occupations. However, in corporate firms, most of the FSTGs work either in administration, finance or R&D departments. In addition, a large proportion takes less paying non S&T jobs for domestic reasons and lack of suitable vacancies. This suggests gross under-utilization of human resource. Some S&T organizations did not have any female working in S&T departments. Recommendations were made to enhance the recruitment, retention and performance of women in S&T employment in Nigeria.