Variation In Olfactory Neuron Repertoires Is Genetically Controlled And Environmentally Modulated

dc.creatorIbarra-Soria
dc.creatorXimena; Nakahara
dc.creatorThiago S.; Lilue
dc.creatorJingtao; Jiang
dc.creatorYue; Trimmer
dc.creatorCasey; Souza
dc.creatorMateus A. A.; Netto
dc.creatorPaulo H. M.; Ikegami
dc.creatorKentaro; Murphy
dc.creatorNicolle R.; Kusma
dc.creatorMairi; Kirton
dc.creatorAndrea; Saraiva
dc.creatorLuis R.; Keane
dc.creatorThomas M.; Matsunami
dc.creatorHiroaki; Mainland
dc.creatorJoel; Papes
dc.creatorFabio; Logan
dc.creatorDarren W.
dc.date2017
dc.dateabr
dc.date2017-11-13T13:44:26Z
dc.date2017-11-13T13:44:26Z
dc.date.accessioned2018-03-29T05:59:04Z
dc.date.available2018-03-29T05:59:04Z
dc.identifierElife. Elife Sciences Publications Ltd, v. 6, p. , 2017.
dc.identifier2050-084X
dc.identifierWOS:000400014600001
dc.identifier10.7554/eLife.21476
dc.identifierhttps://elifesciences.org/articles/21476
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328764
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365789
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ and validate an RNA-sequencing-based method to quantify the abundance of all OSN subtypes in parallel, and investigate the genetic and environmental factors that contribute to neuronal diversity. We find that the OSN subtype distribution is stereotyped in genetically identical mice, but varies extensively between different strains. Further, we identify cis-acting genetic variation as the greatest component influencing OSN composition and demonstrate independence from OR function. However, we show that olfactory stimulation with particular odorants results in modulation of dozens of OSN subtypes in a subtle but reproducible, specific and time-dependent manner. Together, these mechanisms generate a highly individualized olfactory sensory system by promoting neuronal diversity.
dc.description6
dc.descriptionWellcome [098051]
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Sao Paulo [09/00473-0, 2015/50371-0]
dc.descriptionEuropean Molecular Biology Organization Young Investigator Award
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherElife Sciences Publications Ltd
dc.publisherCambridge
dc.relationElife
dc.rightsaberto
dc.sourceWOS
dc.subjectMammalian Odorant Receptors
dc.subjectCopy-number Variation
dc.subjectGene-expression
dc.subjectFunctional Expression
dc.subjectSensory Neurons
dc.subjectMolecular-basis
dc.subjectIn-vivo
dc.subjectMouse
dc.subjectMice
dc.subjectPerception
dc.titleVariation In Olfactory Neuron Repertoires Is Genetically Controlled And Environmentally Modulated
dc.typeArtículos de revistas


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