Aqueous Leaf Extract Of Passiflora Alata Curtis Promotes Antioxidant And Anti-inflammatory Effects And Consequently Preservation Of Nod Mice Beta Cells (non-obese Diabetic)

dc.creatorFigueiredo
dc.creatorD.; Colomeu
dc.creatorTalita Cristina; Gonzalez Schumacher
dc.creatorNayara Simon; Stivanin-Silva
dc.creatorL. G.; Betim Cazarin
dc.creatorCinthia Bau; Molina Meletti
dc.creatorLaura Maria; Romani Fernandes
dc.creatorLuis Gustavo; Prado
dc.creatorMarcelo Alexandre; Zollner
dc.creatorR. L.
dc.date2016
dc.datejun
dc.date2017-11-13T13:22:52Z
dc.date2017-11-13T13:22:52Z
dc.date.accessioned2018-03-29T05:55:38Z
dc.date.available2018-03-29T05:55:38Z
dc.identifierInternational Immunopharmacology. Elsevier Science Bv, v. 35, p. 127 - 136, 2016.
dc.identifier1567-5769
dc.identifier1878-1705
dc.identifierWOS:000376212500015
dc.identifier10.1016/j.intimp.2016.03.031
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S1567576916301175?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327993
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365018
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPassiflora alata Curtis (P. alata) leaves have anti-inflammatory properties; the present study aimed to investigate the anti-diabetogenic properties of P. alata aqueous leaf extract. HPLC analysis identified the phenolic compounds catechin, epicatechin and rutin. The aqueous extract was administered for 30 weeks to non-obese diabetic (NOD) mice presenting a decrease of 28.6% in diabetes incidence and the number of inflammatory cells in pancreatic islets, when compared with the control group (water). The P. alata group presented an antioxidant effect and decreased lipid peroxidation in the serum of NOD mice. Increased numbers of insulin-positive cells were also observed in the pancreatic islets of the treated group. The diabetic group exhibited higher levels in the glucose tolerance test and glycemic index, in comparison to the P. alata-treated group and non-diabetic control BALB/c mice. In addition, the P. alata extract reduced the percentage and the proliferation index of NOD mice lymphocytes submitted to in vitro dose/response mitogenic stimulation assays. These results suggest that the aqueous extract of P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice, and presents potential for use a supporting approach to treat type I diabetes. (C) 2016 Elsevier B.V. All rights reserved.
dc.description35
dc.description127
dc.description136
dc.descriptionState of Sao Paulo Research Foundation (FAPESP) [2011/15763-4]
dc.descriptionCoordination for the Improvement of Higher Education Personnel (Capes)
dc.descriptionCapes
dc.descriptionFAPESP [2011/06559-4, 2013/25256-8]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherElsevier Science BV
dc.publisherAmsterdam
dc.relationInternational Immunopharmacology
dc.rightsfechado
dc.sourceWOS
dc.subjectAnti-inflammatory Effect
dc.subjectPassiflora Elate Curtis
dc.subjectType 1 Diabetes Mellitus
dc.subjectNod Mice
dc.titleAqueous Leaf Extract Of Passiflora Alata Curtis Promotes Antioxidant And Anti-inflammatory Effects And Consequently Preservation Of Nod Mice Beta Cells (non-obese Diabetic)
dc.typeArtículos de revistas


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