Artículos de revistas
Aqueous Leaf Extract Of Passiflora Alata Curtis Promotes Antioxidant And Anti-inflammatory Effects And Consequently Preservation Of Nod Mice Beta Cells (non-obese Diabetic)
Registro en:
International Immunopharmacology. Elsevier Science Bv, v. 35, p. 127 - 136, 2016.
1567-5769
1878-1705
WOS:000376212500015
10.1016/j.intimp.2016.03.031
Autor
Figueiredo
D.; Colomeu
Talita Cristina; Gonzalez Schumacher
Nayara Simon; Stivanin-Silva
L. G.; Betim Cazarin
Cinthia Bau; Molina Meletti
Laura Maria; Romani Fernandes
Luis Gustavo; Prado
Marcelo Alexandre; Zollner
R. L.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Passiflora alata Curtis (P. alata) leaves have anti-inflammatory properties; the present study aimed to investigate the anti-diabetogenic properties of P. alata aqueous leaf extract. HPLC analysis identified the phenolic compounds catechin, epicatechin and rutin. The aqueous extract was administered for 30 weeks to non-obese diabetic (NOD) mice presenting a decrease of 28.6% in diabetes incidence and the number of inflammatory cells in pancreatic islets, when compared with the control group (water). The P. alata group presented an antioxidant effect and decreased lipid peroxidation in the serum of NOD mice. Increased numbers of insulin-positive cells were also observed in the pancreatic islets of the treated group. The diabetic group exhibited higher levels in the glucose tolerance test and glycemic index, in comparison to the P. alata-treated group and non-diabetic control BALB/c mice. In addition, the P. alata extract reduced the percentage and the proliferation index of NOD mice lymphocytes submitted to in vitro dose/response mitogenic stimulation assays. These results suggest that the aqueous extract of P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice, and presents potential for use a supporting approach to treat type I diabetes. (C) 2016 Elsevier B.V. All rights reserved. 35 127 136 State of Sao Paulo Research Foundation (FAPESP) [2011/15763-4] Coordination for the Improvement of Higher Education Personnel (Capes) Capes FAPESP [2011/06559-4, 2013/25256-8] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)