Artículos de revistas
Deregulation Of Soluble Adhesion Molecules In Resistant Hypertension And Its Role In Cardiovascular Remodeling
Registro en:
Circulation Journal. Japanese Circulation Soc, v. 80, p. 1196 - 1201, 2016.
1346-9843
1347-4820
WOS:000377142700022
10.1253/circj.CJ-16-0058
Autor
de Faria
Ana Paula; Versuti Ritter
Alessandra Mileni; Sabbatini
Andrea Rodrigues; Correa
Nathalia Batista; Brunelli
Veridiana; Modolo
Rodrigo; Moreno
Heitor
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Resistant hypertension (RHTN) and target organ damage are linked to increased inflammatory biomarkers, which may regulate adhesion molecules, such as intracellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1); and the platelet (P-selectin) and endothelial (E-selectin) selectins. We investigated a previously unknown relationship between soluble P-selectin (sP-selectin), E-selectin (sE-selectin), ICAM-1 (sICAM-1) and VCAM-1 (sVCAM-1) with RHTN and target organ damage. Methods and Results: We included 110 subjects diagnosed for true RHTN and 112 mild-moderate hypertensive (HTN) patients. Blood pressure parameters, pulse wave velocity and left ventricular mass index (LVMI) were measured. Adhesion molecules were measured on ELISA. Both sP-selectin and sE-selectin were increased; in contrast, sICAM-1 was reduced in RHTN compared with HTN patients, while similar sVCAM-1 was noted in the groups. sP-selectin and sVCAM-1 were elevated in the presence of arterial stiffness (sP-selectin: 104 +/- 47 vs. 89 +/- 45 ng/ml, P<0.05; sVCAM-1: 1,189 +/- 411 vs. 1,060 +/- 412 ng/ml, P<0.05) and cardiac hypertrophy (sP-selectin: 105 +/- 51 vs. 88 +/- 43 ng/ml, P<0.05; sVCAM-1: 1,170 +/- 433 vs. 1,040 +/- 383 ng/ml, P<0.05) in all HTN patients. sP-selectin was associated with target organ damage after adjustment for age and BP. Apart from potential confounders, sE-selectin was a significant indicator of RHTN. Conclusions: The adhesion molecule sP-selectin plays a role in cardiovascular damage, and sE-selectin in resistance to antihypertensive therapy. 80 5 1196 1201 Sao Paulo Research Foundation (FAPESP) National Council for Scientific and Technological Development (CNPq) Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)