Artículos de revistas
Amine Bridges Grafted Mesoporous Silica, As A Prolonged/controlled Drug Release System For The Enhanced Therapeutic Effect Of Short Life Drugs
Registro en:
Materials Science And Engineering: C-materials For Biological Applications. Elsevier Science Bv, v. 72, p. 34 - 41, 2017.
0928-4931
1873-0191
WOS:000392165600005
10.1016/j.msec.2016.11.040
Autor
Rehman
Fozia; Ahmed
Khalid; Airoldi
Claudio; Gaisford
Simon; Buanz
Asma; Rahim
Abdur; Muhammad
Nawshad; Volpe
Pedro L. O.
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Hybrid mesoporous silica SBA-15, with surface incorporated cross-linked long hydrophobic organic bridges was synthesized using stepwise synthesis. The synthesized materials were characterized by elemental analysis, infrared spectroscopy, nuclear magnetic resonance spectroscopy, nitrogen adsorption, X-rays diffraction, thermogravimetry and scanning and transmission electron microscopy. The functionalized material showed highly ordered mesoporous network with a surface area of 629.0 m(2) g(-1). The incorporation of long hydrophobic amine chains on silica surface resulted in high drug loading capacity (21% Mass/Mass) and prolonged release of ibuprofen up till 75.5 h. The preliminary investigations suggests that the synthesized materials could be proposed as controlled release devices to prolong the therapeutic effect of short life drugs such as ibuprofen to increase its efficacy and to reduce frequent dosage. (C) 2016 Elsevier B.V. All rights reserved. 72 34 41 TWAS/CNPq [190064/2010-2] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)