Predicting High Risk Of Exacerbations In Bronchiectasis: The E-faced Score

dc.creatorMartinez-Garcia
dc.creatorM. A.; Athanazio
dc.creatorR. A.; Giron
dc.creatorR.; Maiz-Carro
dc.creatorL.; de la Rosa
dc.creatorD.; Olveira
dc.creatorC.; de Gracia
dc.creatorJ.; Vendrell
dc.creatorM.; Prados-Sanchez
dc.creatorC.; Gramblicka
dc.creatorG.; Corso
dc.creatorPereira M.; Lundgren
dc.creatorF. L.; Fernandes De Figueiredo
dc.creatorM.; Arancibia
dc.creatorF.; Rached
dc.creatorS. Z.
dc.date2017
dc.date2017-11-13T13:15:25Z
dc.date2017-11-13T13:15:25Z
dc.date.accessioned2018-03-29T05:52:58Z
dc.date.available2018-03-29T05:52:58Z
dc.identifierInternational Journal Of Chronic Obstructive Pulmonary Disease . Dove Medical Press Ltd, v. 12, p. 275 - 284, 2017.
dc.identifier1178-2005
dc.identifierWOS:000397754600001
dc.identifier10.2147/COPD.S121943
dc.identifierhttps://www.dovepress.com/predicting-high-risk-of-exacerbations-in-bronchiectasis-the-e-faced-sc-peer-reviewed-article-COPD
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327357
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1364382
dc.descriptionAlthough the FACED score has demonstrated a great prognostic capacity in bronchiectasis, it does not include the number or severity of exacerbations as a separate variable, which is important in the natural history of these patients. Objective: Construction and external validation of a new index, the E-FACED, to evaluate the predictive capacity of exacerbations and mortality. Methods: The new score was constructed on the basis of the complete cohort for the construction of the original FACED score, while the external validation was undertaken with six cohorts from three countries (Brazil, Argentina, and Chile). The main outcome was the number of annual exacerbations/hospitalizations, with all-cause and respiratory-related deaths as the secondary outcomes. A statistical evaluation comprised the relative weight and ideal cut-off point for the number or severity of the exacerbations and was incorporated into the FACED score (E-FACED). The results obtained after the application of FACED and E-FACED were compared in both the cohorts. Results: A total of 1,470 patients with bronchiectasis (819 from the construction cohorts and 651 from the external validation cohorts) were followed up for 5 years after diagnosis. The best cut-off point was at least two exacerbations in the previous year (two additional points), meaning that the E-FACED has nine points of growing severity. E-FACED presented an excellent prognostic capacity for exacerbations (areas under the receiver operating characteristic curve: 0.82 for at least two exacerbations in 1 year and 0.87 for at least one hospitalization in 1 year) that was statistically better than that of the FACED score (0.72 and 0.78, P < 0.05, respectively). The predictive capacities for all-cause and respiratory mortality were 0.87 and 0.86, respectively, with both being similar to those of the FACED. Conclusion: E-FACED score significantly increases the FACED capacity to predict future yearly exacerbations while maintaining the score's simplicity and prognostic capacity for death.
dc.description12
dc.description275
dc.description284
dc.languageEnglish
dc.publisherDove Medical Press Ltd
dc.publisherAlbany
dc.relationInternational Journal of Chronic Obstructive Pulmonary Disease
dc.rightsaberto
dc.sourceWOS
dc.subjectFaced Score
dc.subjectE-faced Score
dc.subjectMortality
dc.subjectBronchiectasis
dc.subjectExacerbations
dc.titlePredicting High Risk Of Exacerbations In Bronchiectasis: The E-faced Score
dc.typeArtículos de revistas


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