Artículos de revistas
How Does The Chain Length Of Peg Functionalized At The Outer Surface Of Mesoporous Silica Nanoparticles Alter The Uptake Of Molecules?
Registro en:
New Journal Of Chemistry. Royal Soc Chemistry, v. 40, p. 8060 - 8067, 2016.
1144-0546
1369-9261
WOS:000382820000094
10.1039/c6nj01316c
Autor
Fonseca
Leandro C.; de Paula
Amauri J.; Martinez
Diego Stefani T.; Alves
Oswaldo L.
Institución
Resumen
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The current work describes the development of new mesoporous silica nanoparticles (MSNs) containing a high content of phenyl groups (hydrophobic species) inside the mesopores and externally functionalized with polyethylene glycol (PEG), a hydrophilic moiety, to provide biocompatibility and colloidal stability. The MSNs were encapsulated with curcumin, a versatile hydrophobic drug for biological use. The ability of silica nanoparticles to optimize the solubility of this biologically-active molecule in water was investigated. Nanoparticles were characterized using C-13 and Si-29 Nuclear Magnetic Resonance (NMR), thermal analysis (TGA and DTA), nitrogen sorption analysis, transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential (PZ). We assessed the curcumin water solubility using the pegylated nanoparticles as well as the influence of the PEG chain length (500 and 2000 Da) and its concentration on the encapsulation process. The results indicate that the higher the PEG chain length the lower the MSN encapsulation capacity for curcumin, possibly due to steric factors. However, all of the nanoparticles largely improved curcumin solubility in water. 40 9 8060 8067 CAPES INCT-Inomat Brazilian Nanotoxicology Network (Cigenanotox) NanoBioss-SisNANO/MCTI Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)