Dietary Interesterified Fat Enriched With Palmitic Acid Induces Atherosclerosis By Impairing Macrophage Cholesterol Efflux And Eliciting Inflammation

dc.creatorAfonso
dc.creatorMilessa Silva; Ferrari Lavrador
dc.creatorMaria Silvia; Koike
dc.creatorMarcia Kiyomi; Cintra
dc.creatorDennys Esper; Ferreira
dc.creatorFabiana Dias; Nunes
dc.creatorValeria Sutti; Castilho
dc.creatorGabriela; Gioielli
dc.creatorLuiz Antonio; Bombo
dc.creatorRenata Paula; Catanozi
dc.creatorSergio; Caldini
dc.creatorElia Garcia; Damaceno-Rodrigues
dc.creatorNilsa Regina; Passarelli
dc.creatorMarisa; Nakandakare
dc.creatorEdna Regina; Lottenberg
dc.creatorAna Maria
dc.date2016
dc.datejun
dc.date2017-11-13T13:12:10Z
dc.date2017-11-13T13:12:10Z
dc.date.accessioned2018-03-29T05:50:25Z
dc.date.available2018-03-29T05:50:25Z
dc.identifierThe Journal Of Nutritional Biochemistry. Elsevier Science Inc, v. 32, p. 91 - 100, 2016.
dc.identifier0955-2863
dc.identifier1873-4847
dc.identifierWOS:000377634300010
dc.identifier10.1016/j.jnutbio.2016.01.005
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S095528631600036X?via%3Dihub
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326820
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1363845
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionInteresterified fats are currently being used to replace trans fatty acids. However, their impact on biological pathways involved in the atherosclerosis development was not investigated. Weaning male LDLr-KO mice were fed for 16 weeks on a high-fat diet (40% energy as fat) containing polyunsaturated (PUFA), TRANS, palmitic (PALM), palmitic interesterified (PALM INTER), stearic (STEAR) or stearic interesterified (STEAR INTER). Plasma lipids, lipoprotein profile, arterial lesion area, macrophage infiltration, collagen content and inflammatory response modulation were determined. Macrophage cholesterol efflux and the arterial expression of cholesterol uptake and efflux receptors were also performed. The interesterification process did not alter plasma lipid concentrations. Although PALM INTER did not increase plasma cholesterol concentration as much as TRANS, the cholesterol enrichment in the LDL particle was similar in both groups. Moreover, PALM INTER induced the highest IL-1 beta, MCP-1 and IL-6 secretion from peritoneal macrophages as compared to others. This inflammatory response elicited by PALM INTER was confirmed in arterial wall, as compared to PALM. These deleterious effects of PALM INTER culminate in higher atherosclerotic lesion, macrophage infiltration and collagen content than PALM, STEAR, STEAR INTER and PUFA. These events can partially be attributed to a macrophage cholesterol accumulation, promoted by apoAl and HDL2-mediated cholesterol efflux impairment and increased Olr-1 and decreased Abca1 and Nr1h3 expressions in the arterial wall. Interesterified fats containing palmitic acid induce atherosclerosis development by promoting cholesterol accumulation in LDL particles and macrophagic cells, activating the inflammatory process in LDLr-KO mice. (C) 2016 Elsevier Inc. All rights reserved.
dc.description32
dc.description91
dc.description100
dc.descriptionState of Sao Paulo Research Foundation (FAPESP) [11/50443-0, 12/50249-2]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageEnglish
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.relationThe Journal of Nutritional Biochemistry
dc.rightsfechado
dc.sourceWOS
dc.subjectAtherosclerosis
dc.subjectInteresterified Fat
dc.subjectTrans Fat
dc.subjectDiet
dc.subjectLipoprotein Metabolism
dc.subjectMice
dc.titleDietary Interesterified Fat Enriched With Palmitic Acid Induces Atherosclerosis By Impairing Macrophage Cholesterol Efflux And Eliciting Inflammation
dc.typeArtículos de revistas


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