Artículos de revistas
Radiotherapy Changes Salivary Properties And Impacts Quality Of Life Of Children With Hodgkin Disease
Archives Of Oral Biology. Pergamon-elsevier Science Ltd , v. 72, p. 99 - 105, 2016.
L. P.; Mendonca
R. H.; Nobre-dos Santos
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)We aimed to perform a longitudinal investigation of the effects of radiotherapy on salivary flow rate, pH, buffering capacity, and protein composition of saliva and on the quality of life of children with Hodgkin disease. Design: Ten children (6-16-year-old) with Hodgkin disease and 10 matched healthy children were investigated. Stimulated and non-stimulated saliva samples were collected at baseline, after 1080 and 2160 cGy of radiation, and 1, 2, and 3 months post-radiotherapy. The salivary flow rate was expressed as mL/min. Buffer capacity was determined by titration. Amylase activity, immunoglobulin A, mucin, and lactoferrin concentrations were determined by ELISA. Quality of life was assessed by Quality of Life Head and Neck module 35 questionnaire. Results: We found that radiotherapy caused hyposalivation at 1080 cGy and 1 month after radiotherapy and reduced buffering capacity at 2160 cGy. Mucin concentration and amylase activity in non-stimulated saliva increased 1 month after radiotherapy. Lactoferrin concentration increased during and after radiotherapy. Immunoglobulin A concentration increased at 1080 cGy, 1 and 2 months, for non stimulated saliva and at 2160 cGy and 1 month for stimulated saliva. Children reported more pain after radiotherapy and more xerostomia during radiotherapy. Conclusion: We concluded that the radiotherapy protocol affected the children's salivary properties and children's quality of life. (C) 2016 Elsevier Ltd. All rights reserved.7299105Sao Paulo Research Foundation (FAPESP) [2012/02858-0]FAPESP [2012/14699-3]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)