90-kda N-domain Angiotensin I-converting Enzyme (ace): Possible Marker For Hypertension In A Renal Transplant Model

Enzima Conversora De Angiotensina I (eca) N-domínio 90-kda: Possível Marcador Para Hipertensão Em Modelo De Transplante Renal

dc.creatorLeite
dc.creatorCleber A; Bertoncello
dc.creatorNádia SC; Watanabe
dc.creatorIngrid KM; Fernandes
dc.creatorFernanda B; Andrade
dc.creatorMaria Claudina C; Ronchi
dc.creatorFernanda A; Arita
dc.creatorDanielle Y; Marcondes
dc.creatorFernanda K; Cunha
dc.creatorTatiana S; Casarini
dc.creatorDulce E
dc.date2017
dc.date2017-08-30T17:38:01Z
dc.date2017-08-30T17:38:01Z
dc.date.accessioned2018-03-29T05:31:02Z
dc.date.available2018-03-29T05:31:02Z
dc.identifierJornal Brasileiro De Nefrologia. Sociedade Brasileira De Nefrologia, v. 39, n. 1, p. 11 - 14
dc.identifier0101-2800
dc.identifierS0101-28002017000100011
dc.identifierhttp://www.scielo.br/scielo.php?pid=S0101-28002017000100011&script=sci_arttext&tlng=pt
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/324969
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1359187
dc.descriptionHypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
dc.description39
dc.description1
dc.description11
dc.description14
dc.languageIngles
dc.publisherSociedade Brasileira de Nefrologia
dc.relationJornal Brasileiro de Nefrologia
dc.rightsaberto
dc.sourceScielo
dc.subjectHypertension
dc.subjectKidney Transplantation
dc.subjectRenin-angiotensin System
dc.subjectHipertensão
dc.subjectSistema Renina-angiotensina
dc.subjectTransplante De Rim
dc.title90-kda N-domain Angiotensin I-converting Enzyme (ace): Possible Marker For Hypertension In A Renal Transplant Model
dc.titleEnzima Conversora De Angiotensina I (eca) N-domínio 90-kda: Possível Marcador Para Hipertensão Em Modelo De Transplante Renal
dc.typeArtículos de revistas


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