Artículos de revistas
Ultrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines
Registro en:
Journal Of The Brazilian Chemical Society. Sociedade Brasileira De Química, v. 28, n. 2, p. 217 - 224
0103-5053
S0103-50532017000200217
Autor
Santos
Eric F. S. dos; Cury
Nathália M.; Nascimento
Tainara A. do; Raminelli
Cristiano; Casagrande
Gleison A.; Pereira
Claudio M. P.; Simionatto
Euclésio; Yunes
José A.; Pizzuti
Lucas
Institución
Resumen
3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4;11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 µmol L-1 and five compounds presented IC50 values around 40 µmol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 µmol L-1. 28 2 217 224