Artículos de revistas
Semaphorins And Neuropilins Expression In Salivary Gland Tumors
Registro en:
1600-0714
Journal Of Oral Pathology & Medicine. WILEY-BLACKWELL, n. 45, n. 2, p. 119 - 126.
0904-2512
WOS:000369988600007
10.1111/jop.12341
Autor
Fonseca
FP; Bingle
L; Santos-Silva
AR; Lopes
MA; de Almeida
OP; de Andrade
BAB; Mariano
FV; Kowalski
LP; Rangel
ALCA; Martins
MD; Meurer
L; Speight
PM; Vargas
PA
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Salivary gland tumors (SGT) account for 3-10% of all head and neck neoplasms, and little is known about their angiogenic properties. Despite semaphorins and neuropilins have been demonstrated to be prognostic determinants in many human cancers, they remain to be investigated in SGT. Therefore, the objective of this study was to analyze the clinical significance of the expression of class 3 semaphorins A (Sema3A) and B (Sema3B) and neuropilins-1 (Np-1) and neuropilins-2 (Np-2), in SGT. MethodsTwo hundred and forty-eight SGT were organized in tissue microarray paraffin blocks and expression of CD34, Sema3A, Sema3B, Np-1, and Np-2 was determined through immunohistochemistry. The immunoreactions were quantified using digital algorithms and the results correlated with clinicopathological parameters. ResultsMalignant tumors had an increased vascular density than their benign counterparts and their increased vascular area significantly correlated with recurrences (P<0.05). Patients older than 40years and the presence of recurrences determined an inferior survival rate (P=0.0057 and P=0.0303, respectively). In normal salivary glands, Np-1 and Np-2 expression was restricted to ductal cells, whereas Sema3A and Sema3B were positive in the serous acinar compartment. Tumors were positive for all markers and the co-expression of Np-1/Np-2 significantly correlated with the presence of paresthesia and advanced stages of the tumors (P=0.01 and P=0.04, respectively). ConclusionSema3A, Sema3B, Np-1, and Np-2 may be involved in the pathogenesis of SGT, but their expression did not present a statistically significant prognostic potential in this study. 45
119 126 Sao Paulo State Research Foundation (Brazil) [2009/53839-2, 2012/07519-9, 2012/10781-7] Brazilian Coordination of Higher Education [CAPES/PDSE 2892/13-8] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)